- The BioSpad project (ICFO / IFAE) develops more affordable brain diagnostic tests and the BioVac project (ICN2 / IBEC) populates nanoparticles with antigens to create a new generation of vaccines against untreatable infections and multi-resistant bacteria
- The 2020 BIST Ignite Awards Ceremony will be held on March 11th in the La Pedrera Auditorium
The BioSpad and BioVac research projects are the recipients of the 2020 BIST Ignite Awards, endowed with 50,000 euros each. BioSpad is co-led by the ATLAS Píxels group (ICREA Prof. Sebastian Grinstein), of the Institute for High Energy Physics (IFAE), the Medical Optics group (ICREA Prof. Turgut Durduran), of The Institute of Photonic Sciences (ICFO), and the Radiation Detectors group (Dr. Salvador Hidalgo), of the Institute of Microelectronics of Barcelona (IMB-CNM). The BioVac project is a collaboration of the Nanostructured Functional Materials group (Dr. Daniel Ruiz), of the Catalan Institute of Nanoscience and Nanotechnology (ICN2), and Bacterial Infections: Antimicrobial Therapies group (Dr. Eduard Torrents), of the Institute for Bioengineering of Catalonia (IBEC). This contribution will allow these groups, hosted in centres of the Barcelona Institute of Science and Technology, to further develop both projects, each responding to an important unmet medical need.
Cortical blood flow is a biomarker of health and proper functioning of the brain. Alterations in the supply of oxygen through the blood can cause serious degradation in neural function and, therefore, the monitoring of cerebral blood flow has become an important tool for the diagnosis and control of diseases associated with ischemia and other vascular pathologies such as cancer and stroke.
Diffuse Correlation Spectroscopy (DCS) is a non-invasive diagnostic test developed in recent years that allows the measurement of cerebral blood flow. DCS uses an infrared light source to access the cerebral cortex, and by studying how photons propagate in the tissue, obtain information about blood flow therein. The ability of DCS to measure tissue hemodynamics also makes it suitable for monitoring and control of treatments such as chemotherapy, radiotherapy or arterial revascularization.
Current limitations to the use of DCS in medical applications is its cost, since detectors capable of “reading” the information supplied by the photons are expensive —a few thousand euros per device—, as a consequence of their non-standardized production system. In contrast, the prototype developed by the IFAE and ICFO groups, within the framework of the BioSpad project, “permits their standardized production, in the same way chips for mobile phones or computers are manufactured”, explains Prof. Sebastian Grinstein (IFAE).
“What we have done is adapt silicon detectors we use in the detection of fundamental particles in large accelerators such as CERN, sensitive enough to capture even a single photon, to create a prototype that allows series manufacturing, which will reduce production cost almost 100 times”, adds the researcher.
“The non-invasive detection of blood flow in tissues is of great importance for the diagnosis and treatment of many diseases. This project will facilitate the transfer of our technologies to many more health applications that can help thousands of patients”, says Prof. Turgut Durduran (ICFO).
The first phase of the project, which started a year ago thanks to a 20,000 euro grant through the BIST Ignite programme, has demonstrated the feasibility of producing a device that fulfils a large part of the requirements for the DCS using CMOS industrial standards. With the endowment of the 2020 BIST Ignite Award, the winning groups will further develop the device design. “We will work to integrate in a single chip the detection, amplification, digitalization and processing of photons, which will allow us to move towards miniaturization and think of wearable devices for remote monitoring or the prevention of vascular risks”, says Prof. Grinstein.
The evaluation panel noted in particular that the BioSpad project responds to an important unmet medical need and, consequently, has a very high market potential. The panel also stressed that the team had actively sought external collaborations, resulting in the Barcelona Microelectronics Institute (IMB-CNM-CSIC) joining the project as a partner. The project has also attracted the attention of an Italian chip manufacturer that could participate in the production of the device. If expectations are met, a new DCS device could reach the market in three to four years.
It is estimated that in 2050 about 12 million people will die around the world because of infectious diseases. The reason is two-fold. First, antibiotics are becoming less effective due to the resistance developed by the bacteria to antimicrobial treatments. Second, there are still several infectious diseases for which most of the vaccines used nowadays, mainly based on live-attenuated pathogens, are ineffective. The BioVac project, a collaboration of the Nanostructured Functional Materials (Nanosfun) group of ICN2, and the Bacterial Infections: Antimicrobial Therapies (BIAT) group of IBEC, address these challenges with an innovative approach.
The hypothesis behind the project is that polymeric particles that mimic the size and shape of the target bacteria, and incorporate antigens from this pathogen, could cause the immune system to produce an immune reaction better than by administering the antigens alone, and without the risks and limitations of introducing attenuated bacteria.
“The first phase of the project demonstrated, through in vitro and in vivo experiments, that functionalized biomimetic nanoparticles achieve an immune response superior to the administration of free antigens and allowed us to identify the most efficient combinations of antigens”, explains Prof. Daniel Ruiz (ICN2). “The BIST Ignite Award will allow us, during the second phase of the project, to investigate the optimization of antigen combinations and test the concept with new bacterial cells for which there is currently no vaccine available”, adds Dr. Claudio Roscini, postdoctoral researcher at the same ICN2 group.
The evaluation panel valued that the project features a simple and elegant concept with a clear short-term biomedical application. It also underscored the highly productive first phase and the clarity of the objectives and work plan for the second phase, as well as the potential of the project to raise funds from public administrations and private foundations to allow the project to reach a clinical phase.
The 2020 BIST Ignite Awards will be presented at a ceremony held on March 11, at 6.00PM, at the La Pedrera Auditorium. At the event, BIST will announce the five projects selected in the 2019 BIST Ignite programme call. These projects will receive 20,000 euros each to fund an initial eight-month development phase, and will compete for one of two 2021 BIST Ignite Awards based on their results.
Since the inception of the BIST Ignite programme in 2016, eight BIST Ignite Awards (THEIA, INWOC, GENSTORM, ENGUT, Q-SPET, PHASE-CHROM, BIOSPAD y BIOVAC) have been given out, including the two presently announced. They were selected from among 18 initial-phase projects funded through yearly competitive calls. In total, these projects have received 760,000 euros in funding from BIST and have involved over 150 researchers. Additional information about the BIST Ignite Programme can be found here.
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