Group leader and ICREA professor Pau Gorostiza, working at the BIST Centre IBEC, has won the research grant ‘FUNDALUCE 2016’ for a project that aims to develop prosthetic molecular switches that could replace degenerated photoreceptors in the retina to restore vision.
“Fotoconmutadores covalentes para el control remoto de receptores endógenos”, which will be carried out with collaborators at IQAC-CSIC, the Universidad Miguel Hernández, Universidad de Alcalá de Henares and the Instituto de Neurociencias de Alicante, proposes the concept of nanoprosthesis: that if a functional characteristic of an organ or tissue is regulated by a given receptor, it should be possible to use directed covalent photoswitches to control that particular receptor with light, thereby manipulating their function.
“In optogenetics we can photocontrol neuronal activity with light using genetic manipulation of the target cells, and photopharmacology affords equivalent results using light regulated drugs,” explains Dr. Gorostiza. “Our project’s strategy aims to replace degenerate photoreceptors with molecular prosthetic ‘switches’, and is applied in tissue that is naturally accessible to light: the eye.”
The project, a chemical tour de force, is based on a method to synthesize amine-containing compounds that can link covalently with the target protein in the retina without genetic manipulation. “If the vision restoration capability of these small molecules can be demonstrated in vivo, their translational impact will be very high and safety testing could begin immediately,” says Pau.
Within the framework of the Federación de Asociaciones de Retinosis Pigmentaria de España (FARPE), the Fundación Lucha Contra la Ceguera (FUNDALUCE) maintains and manages a National Research Fund for the promotion of scientific and medical research for the prevention, treatment and cure of hereditary and degenerative diseases of the retina, mainly Retinitis Pigmentosa, a progressive loss of vision in which the patient suffers night blindness, a reduction in peripheral vision, loss of visual acuity, small flashes that hinder the vision, or changes in the perception of colors. The evaluation of eight projects that were submitted to the 2016 FUNDALUCE call was carried out by MINECO’s Agencia Nacional de Evaluación y Prospectiva (ANEP) and an Advisory Committee made up of expert ophthalmologists from FARPE and FUNDALUCE.
More information on the IBEC website.