Transcriptional regulation by the orphan nuclear receptor NR5A2 links cell differentiation with inflammation in the pancreas

Event Details

  • Date:
  • Venue: IRB Barcelona - Aula Fèlix Serratosa
  • Address: Parc Científic de Barcelona - C/ Baldiri Reixac, 4-12, 08028 Barcelona

Speaker: Francisco Real, MD, PhD, Epithelial Carcinogenesis Group, Centro Nacional de Investigaciones Oncológicas (CNIO) Madrid (Spain)

Organizer: IRB Barcelona

Host: Dr.Eduard Batlle, IRB Barcelona


It is thought that tissue-specific differentiation and inflammatory programs independently contribute to cancer. Using a combination of murine and human data, we show that the orphan nuclear receptor NR5A2 is not only a key regulator of pancreas differentiation but also a major regulator of inflammatory programs. Upon genetic and pharmacological perturbation, Nr5a2 undergoes a dramatic transcriptional switch relocating from tissue-specific to inflammatory loci in an AP-1-dependent manner. These findings provide compelling evidence that the same transcriptional networks supporting homeostasis can be subverted to foster inflammation upon genetic or environmental constraints.