BIST Colloquium Series 2021-22
Synthetic developmental biology: Cross-species comparison and manipulation of organoids
IRB Barcelona BioMed Seminar by Miki Ebisuya, PhD., Group Leader, EMBL Barcelona
Host: Marco Milán, PhD – Development and Growth Control Lab – Mechanisms of Disease Programme – IRB Barcelona
Abstract:
While mechanisms of embryonic development are well conserved among mammals, the progression speed tends to be slower in larger species. To study differences in time between species, my group uses in vitro systems. We have recently recapitulated the segmentation clock, oscillatory gene expression during early development, from human and mouse pluripotent stem cells. The oscillation period of the human segmentation clock is 5-6 hours, while the mouse period is 2-3 hours. We found that this period difference between species stems from slower biochemical reactions in human cells, including slower protein degradation and longer delays in gene expression processes. Now we are extending this approach of cross-species comparison to other mammalian species, including cows and rhinos, and other developmental processes. In parallel, we develop genetic tools to manipulate developmental processes and organoids.
Important: For attendees outside the PCB community you must register at least 24hours before the seminar.
This colloquium is part of the BIST Master of Multidisciplinary Research in Experimental Sciences curriculum but is also open and free for anyone interested in participating. If you want to assist please send an email to education@bist.eu
