Structure and dynamics of Smad complexes

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IRB Barcelona Biomed Webinar by Dr Maria J. Macias

Group Leader – Structural Characterization of Macromolecular Assemblies Lab – Mechanisms of Disease Programme – IRB Barcelona

Host: Manuel Palacín, PhD –  Amino Acid Transporters and Disease Lab – Aging & Metabolism Programme – IRB Barcelona



Our lab aims to describe how biological processes occur and their role in human diseases using high-resolution structural biology. A large part of our work is devoted to clarify the role of SMAD transcription factors in TGF-β signaling. I will present our results related to complex structures of Smad proteins and two cofactors, and the conformational landscape that two Smads FL proteins adopt in solution. I will also take the opportunity to comment on the AlphaFold2 and RoseTTAfold programs.


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