DNA-based nanodevices for the detection of diagnostic antibodies

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By Prof. Francesco Ricci, Chemistry Department, University of Rome, Tor Vergata, Rome, Italy

Abstract: Nature has invented a number of tricks and strategies by which the behaviour of proteins and other biomolecular machines can be finely controlled. These highly optimized and evolved mechanisms allow to control biological pathways with different chemical and environmental stimuli and are at the basis of the high specificity and selectivity of biomolecular machines.

Motivated by the above arguments we have characterized and recreated in-vitro several mechanisms to control the response of DNA-based nanodevices for diagnostic and drug-delivery applications. Using these mechanisms we can finely control the activity of DNA-based nanodevices with different chemical and environmental stimuli including pH, antibodies, enzymes, small molecules and electronic inputs.

I will present an overview of the most representative and recent examples developed in our lab in the above research directions focusing on examples of DNA-based nanodevices controlled by antibodies for diagnostic applications.

Hosted by: Prof. Arben Merkoçi, Nanobioelectronics and Biosensors Group Leader at ICN2


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