eTANGO was awarded the BIST Ignite Grant in April, 2017. The news release can be found here.
eTANGO will employ a multidisciplinary approach that combines state-of-the-art genetic manipulations of the protein TANGO1 and its binding partners together with advanced optical techniques and biophysical modeling to monitor the organization and dynamics of collagen export from the endoplasmic reticulum (ER). By merging the know-how of the collaboration, eTANGO will be able to provide for the first time a quantitative description of the spatiotemporal events that lead to collagen export from the ER.
Multidisciplinarity within eTANGO
eTANGO is truly a multidisciplinary project that aims to provide quantitative molecular and physical understanding of a process of fundamental and translation importance, i.e., collagen export. This is uniquely achieved by establishing collaboration between experts in molecular & cell biology at CRG (Malhotra’s lab) and physicists & biophysicists at ICFO (Garcia-Parajo’s lab). eTANGO merges multidisciplinary elements that include (i) molecular biology tools; (ii) advanced microscopy techniques and quantitative data and image analysis to visualize the structure and dynamics of membranes and proteins with unprecedented spatial and temporal resolution; and (iii) theoretical membrane biophysics to identify different forces that remodel membrane shape during the formation of the collagen-containing carriers.
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